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Quick Answer: How does chloroquine treat malaria?

Chloroquine phosphate is used to prevent and treat malaria. It is also used to treat amebiasis. Chloroquine phosphate is in a class of drugs called antimalarials and amebicides. It works by killing the organisms that cause malaria and amebiasis.

How does chloroquine prevent malaria?

Do not take any medicine that contains chloroquine unless prescribed by your doctor. Chloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito.

Is chloroquine effective against malaria?

Chloroquine is active against the erythrocytic forms (Fig. 6.3) of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P.

What does chloroquine do to Plasmodium?

Chloroquine is a member of the drug class 4-aminoquinoline. As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell.

What stage of malaria does chloroquine treat?

As described above, chloroquine acts on the asexual erythrocytic stage of malarial parasites (it is a blood schizonticide). In addition, chloroquine also exerts activity against the gametocytes of P. vivax, P. ovale and P.

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Is chloroquine an immunosuppressant?

Chloroquine and its synthetic analogue, hydroxychloroquine also belong to the disease-modifying anti-rheumatic drug class because these drugs are immunosuppressive.

Why was chloroquine discontinued malaria?

Background. Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites.

Who should not take chloroquine?

low blood sugar. glucose-6-phosphate dehydrogenase (G6PD) deficiency. low amount of magnesium in the blood. low amount of potassium in the blood.

How does chloroquine inhibit autophagy?

Chloroquine (CQ), which is frequently used clinically as an antimalarial agent, is a classic inhibitor of autophagy that blocks the binding of autophagosomes to lysosomes by altering the acidic environment of lysosomes, resulting in the accumulation of a large number of degraded proteins in cells (8).

How is chloroquine-resistant falciparum malaria treated?

Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole.

What Genotype protects against malaria?

Sickle cell trait (genotype HbAS) confers a high degree of resistance to severe and complicated malaria [1–4] yet the precise mechanism remains unknown.

Which malaria is resistant to chloroquine?

Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

What does chloroquine do to the body?

Chloroquine phosphate is used to prevent and treat malaria. It is also used to treat amebiasis. Chloroquine phosphate is in a class of drugs called antimalarials and amebicides. It works by killing the organisms that cause malaria and amebiasis.

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Why is chloroquine or quinine not often used to treat malaria anymore?

Chemoprophylaxis and treatment of falciparum malaria are becoming more complex because P. falciparum is increasingly resistant to various antimalarial drugs. Chloroquine can no longer be used for prevention and treatment of falciparum malaria.

Is chloroquine reversible?

Antimalarials. The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy (cornea verticillata) and, more importantly, an irreversible sight-threatening maculopathy.

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