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Often asked: Does tetrabenazine cause weight gain?

Weight increase was 0.8 lb/mo in the tetrabenazine group compared with 1.7 lb/mo in the neuroleptic group (P =. 006). Most patients who switched from a neuroleptic drug to tetrabenazine subsequently lost weight.

What are the side effects of tetrabenazine?

Tetrabenazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • diarrhea.
  • vomiting.
  • decreased appetite.
  • headache.
  • pain or burning upon urination.
  • bruising.
  • difficulty speaking or being understood.

Is tetrabenazine an antipsychotic?

Tetrabenazine (TBZ) was initially synthesized in the 1950s by O Schneider and A Brossi at the research laboratory of Hoffmann-La Roche in Basel. They created TBZ as an antipsychotic drug as part of their research into simpler chemical compounds with reserpine-like activity.

How quickly does tetrabenazine work?

When will tetrabenazine start working? Improvements may be seen in as little as 1 to 2 weeks. However, it can sometimes take up to 6 weeks to see the full benefits of the medication.

Can you just stop taking tetrabenazine?

You should not stop using tetrabenazine suddenly or your symptoms may return. Talk to your doctor before you stop taking this medicine.

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Can you drink alcohol while taking tetrabenazine?

Alcohol can increase the nervous system side effects of tetrabenazine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with tetrabenazine.

Can tetrabenazine cause insomnia?

The most common side effects included drowsiness (36.5%), parkinsonism (28.5%), depression (15.0%), insomnia (11.0%), nervousness or anxiety (10.3%), and akathisia (9.5%). The side effects were controlled with reduction in the dosage.

What is another name for tetrabenazine?

Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the U.S. Food and Drug Administration approved the use of tetrabenazine to treat chorea associated with Huntington’s disease.

Can tetrabenazine be crushed?

See prescribing information for converting patients from tetrabenazine. Deutetrabenazine can be discontinued without tapering but must be retitrated if stopped for greater than one week. Administer with food and swallow tablets whole; do not crush, break or chew. dose is 36 mg (18 mg twice daily).

What does tetrabenazine do to dopamine?

Nervous system. Tetrabenazine inhibits vesicular monoamine transporter 2, leading to depletion of dopamine and other monoamines in the central nervous system.

What is tetrabenazine FDA approved for?

Xenazine (tetrabenazine) is a selective and reversible centrally-acting dopamine depleting drug indicated for the treatment of chorea associated with Huntington’s disease.

What is tetrabenazine MOA?

Tetrabenazine is a reversible human vesicular monoamine transporter type 2 inhibitor (Ki = 100 nM). It acts within the basal ganglia and promotes depletion of monoamine neurotransmitters serotonin, norepinephrine, and dopamine from stores. It also decreases uptake into synaptic vesicles.

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What is the side effects of clonidine?

Side Effects

  • Anxiety.
  • blistering, burning, crusting, dryness, or flaking of the skin.
  • chest pain or discomfort.
  • confusion as to time, place, or person.
  • decreased urine output.
  • dilated neck veins.
  • fast, pounding, or irregular heartbeat or pulse.
  • general feeling of discomfort or illness.

What is the difference between Deutetrabenazine and tetrabenazine?

Deutetrabenazine (Austedo) is a novel molecule that replaces 6 hydrogen atoms in the tetrabenazine molecule with 6 atoms of deuterium, a non-radioactive hydrogen isotope. This replacement gives deutetrabenazine greater stability and a longer half-life than tetrabenazine.

What is the medicine carbamazepine used for?

Carbamazepine is a medicine used to treat epilepsy. It can also be taken for nerve pain caused by diabetes (peripheral neuropathy) or if you have a painful condition of the face called trigeminal neuralgia. Carbamazepine is occasionally used to treat bipolar disorder when other medicines have not worked.

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