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What are cardiac glycosides used to treat?

Cardiac glycosides are medicines for treating heart failure and certain irregular heartbeats. They are one of several classes of drugs used to treat the heart and related conditions. These drugs are a common cause of poisoning.

When do you use cardiac glycosides?

Cardiac glycosides are used to treat patients with atrial fibrillation and atrial flutter. In addition, they can be prescribed for congestive heart failure when the use of other medications fails.

What do cardiac glycosides do to blood pressure?

Background: For the past two decades, it has generally been accepted (‘Blaustein hypothesis’) that cardiac glycosides such as ouabain and digoxin increase the sodium and calcium content of smooth muscle cells, so inducing arterial vasoconstriction and a rise in blood pressure.

What is the mechanism of action of cardiac glycosides?

Mechanism of action and toxicity Cardiac glycosides inhibit the Na+‐K+‐ATPase on cardiac and other tissues, causing intracellular retention of Na+, followed by increased intracellular Ca2+ concentrations through the effect of the Na+‐Ca2+ exchanger.

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Why are cardiac glycosides useful for treating heart patients?

Cardiac glycosides, particularly digoxin, have been used in the clinic for over 200 years. At therapeutic levels, they exert a positive inotropic effect (an increase in contractile force) on the heart muscle, thus improving circulation in cases of insufficient cardiac output.

What are examples of cardiac glycosides?

Cardiac glycosides include:

  • Digoxin (Lanoxicaps, Lanoxin, Digibind)
  • Digitoxin (Crystodigin)

How cardiac glycosides help in CHF?

Cardiac glycosides have long served as the main medical treatment to congestive heart failure and cardiac arrhythmia, due to their effects of increasing the force of muscle contraction while reducing heart rate.

What are side effects of cardiac glycosides?

The most common side effects include dizziness, fatigue, headache, anxiety, gastrointestinal upset, change in taste and blurred vision. Severe side effects include seizures and coma, heart block, atrial and ventricular arrhythmias and sudden cardiac death.

What is digoxin used for?

Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.

Why is digoxin the only cardiac glycoside?

Digoxin. Digoxin is a cardiac glycoside that inhibits Na+-K+ ATPase in the cardiomyocyte, resulting in increased intracellular Na+ concentration, thereby increasing intracellular Ca2+ through a Na+-Ca2+ exchange mechanism.

How does digoxin help the heart?

Digoxin is a type of drug called a cardiac glycoside. Their function is to slow your heart rate down and improve the filling of your ventricles (two of the chambers of the heart) with blood. For people with atrial fibrillation, where the heart beats irregularly, a different volume of blood is pumped out each time.

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Which test are used for detection of cardiac glycosides?

A digoxin test is a blood test that your doctor can use to determine the level of the medication digoxin in your blood. Digoxin is a drug of the cardiac glycoside group. People take it to treat heart failure and irregular heartbeats.

What do you mean by glycosides?

Glycosides can be defined as the compounds in which one or more sugars are combined with nonsugar molecules through glycosidic linkage.

Is digitalis and digoxin same?

Digoxin, also called digitalis, helps an injured or weakened heart pump more efficiently. It strengthens the force of the heart muscle’s contractions, helps restore a normal, steady heart rhythm, and improves blood circulation. Digoxin is one of several medications used to treat the symptoms of heart failure.

What effect do cardiac glycosides have on the conduction system of the heart?

Cardiac glycosides suppress enhanced atrioventricular conduction and do not affect it provided it remains within normal. The mechanisms by which cardiac glycosides may act are discussed: extracardiac, cholinomimetic (in the acute test and direct one) and influencing heart conduction components (when used continuously).

Why Digoxin is used in atrial flutter?

Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate.

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